Pramipexole

Pramipexole is a highly potent dopamine agonist in the same class as Cabergoline, recognized for its powerful role in regulating prolactin levels. By significantly enhancing dopamine activity in the brain, it directly suppresses prolactin production. Its binding affinity to the dopamine D3 receptor is particularly notable—approximately seven times stronger than any other dopamine agonist—making it exceptionally effective in this regard.

While it also interacts with D2 receptors, its dominance at the D3 receptor level is what sets Pramipexole apart. Within performance enhancement settings, it is often valued for its ability to manage prolactin-related side effects from compounds such as trenbolone or nandrolone (Deca-Durabolin). By lowering prolactin, it helps reduce issues such as gynecomastia, lactation, and diminished libido, while also supporting improved mood, motivation, and potential neuroprotective benefits.